1. Which of the following types of bonds wouldbe LEAST likely in a receptor-ligand interaction?
Ionic bond
Covalent bond
Hydrogen bond
Hydrophobic interaction
Ionic bond
2. Ka, the association constant, is a measureof which of the following?
The concentration of unbound ligand
The concentration of unboundreceptor
The affinity of receptor for ligand
The size of the receptor relative to theligand
The number of ligands for eachreceptor
3. Receptors that are multivalent tend to bindto their ligands more strongly than receptors with a single bindingsite. What is the term used to describe this phenomenon?
Avidity
Valency
Affinity
Magnetism
None of the above
4. Which of the following BEST describes howcytokines are released from activated T cells?
Cytokines are released near where T-cellreceptors are clustered.
-
T cells release cytokines on the side of thecell opposite the MTOC in order to more efficiently
distribute the response around thecell.
T cells release cytokines evenly around thecell.
Cytokines are released in short bursts frompre-formed vesicles full of cytokines.
Cytokines are released in whatever directionthe MTOC happens to be facing upon TCR ligation.
5. Receptors that dimerize upon ligand bindingoften contain______________in their cytoplasmic domains.
tyrosine kinases
hydrophobic regions
proteases
metal-binding regions
large immunoglobulin folds
6. Portions of the cytoplasmic domains of manyimmune receptors are targets for phosphorylation. These domains areknown as:
Grb domains.
ITAMs.
leucine zipper motifs.
SOS domains.
None of the above