MIMM 214 Midterm: Midterm Review (Lectures 9-11)
15 Mar 2017
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Tnf- : secreted by macrophages; work in migration of innate cells; dilate blood vessels, more coagulation. Systemic: macrophages activated in liver & spleen; they secrete tnf- into the bloodstream. Acute phase response: quick, first response to infection & inflammation. Production of c-reactive proteins (opsonize bacteria; activating classical complement) Mbl is a prr that circulates in blood; triggers the. If you have lots of c-reactive proteins in your blood --> sign of infection & inflammation. Act in: acute phase response; cell migration; fever. Ilcs and nks have same lymphoid progenitor; both non- specific => innate immunity (contrast with b&t lymphoids which are adaptive) Activated by cytokines produced by dcs, or other cells. Nks: don"t change; innate; have inhibitory receptors & activating receptors. Normally: receive both activating & inhibitory signal from cell; does not kill normal cell. If target cells do not have mhc i, they"d be killed! Since no inhibitory signal to stop nk; there"s only the activating signal.
