NSCI 200 Study Guide - Final Guide: Retina, Neuroligin, Alternative Splicing
22 Jun 2016
School
Department
Course
Professor
Document Summary
Lectures 16 & 17 : factors involved in early brain development. = formation of primary and secondary brain and secondary brain vesicles. Low bmp causes mutations in the lmx1a protein, a tf regulating insulin production. Induce ectoderm to form neural tissue by antagonizing members of the bmp family. antagonizing members of the bmp family. Fgf-8 bcd (bicoid) kr (kruppel) h (hairy) wg (wingless) Induces expression of engrailed (a transcription factor) Normally encodes a halter at the t3 segment. De ciency leads to the expression of another pair of wings. Segmentation and regionalization of cns (including cranial nerve nuclei) but mainly hindbrain. Notochord expresses shh, then the presence of shh induces its expression in the. These lead to diseases such as lissencephaly. Lecture 18: construction of neural circuits - ligands & receptors involved in axon guidance. Allow adhesion of growth cone to extracellular matrix. Homophilic cell adhesion molecules ( like & like binding)
