How did inoculation with cowpox generate immunological memory and provide protection against smallpox? Did cross-reactivity play a role?
How did PasteurΓ’ΒΒs work with attenuated (weakened) bacteria further our understanding of the role vaccination can play?
What are the three characteristics that define an adaptive immune response? Briefly define each of the characteristics.
Define primary versus secondary immune response.
WhatΓ’ΒΒs the difference between totipotent, pluripotent, multipotent and oligopotent when evaluating cell differentiation capacity?
What is hematopoiesis?
What cell types are derived from myeloid versus lymphoid progenitor cells? Describe the function of each WBC type.
What is clonal selection?
What role do antibodies play with regard to antigen recognition and immune defense that is different from what Tcrs provide?
As described in class generally understand the outcome of B cell, Th cell, and Tc cell activation. Understand that these cells can differentiate into effector (plasma cells, cytokine producing Th cells and CTLs) or memory cells.
Understand how granzymes and perforins play a role in apoptosis.
Which types of cells typically express MHC Class II? Do these cell types also express MHC Class I, and if so why?
With regard to Tc and Th cells, what kinds of peptide antigens (think about exogenously versus endogenously derived antigens) are recognized?
Be able to show cooperation between Tc, Th and B cell responses (refer to class notes).
What is the overall role of MHC Class I and II?
What is ADCC and what cell types are involved?
Understand and be able to provide examples highlighting the cooperation between innate and adaptive immunity. Note: ADCC and dendritic cell and macrophage interactions with Th cells illustrate examples of innate/adaptive cooperation.
What are the primary lymphoid organs? What role do they play?
What role does the lymphatic circulatory system play in immune defense?
WhatΓ’ΒΒs the difference between plasma, ISF, and lymph?
WhatΓ’ΒΒs the difference between afferent and efferent lymphatic vessels?
How is lymph ultimately delivered back to blood?
Define extravasation. Why is this important?
What are HEVs and what role do they play?
What are the secondary lymphoid tissues/organs?
What role do lymph nodes play?
What role does the spleen play?
What is Leukocyte Adhesion Deficiency?
WhatΓ’ΒΒs MALT and its role?
What is the inflammatory response and what are characteristics associated with inflammation?
What role does histamine play in the inflammatory response?
