PHAR 300 Study Guide - Final Guide: Ankylosing Spondylitis, Nonsteroidal Anti-Inflammatory Drug, Cytochrome C Oxidase Subunit Ii
10 Jan 2019
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Salicylic acid (salicilin), acetylsalicylic acid (asa tradename aspirin), ibuprofen. Although technically not nsaids, acetaminophen is usually classified with them. The first discovered was salicilin, from the salix genus of plants. Aspirin: spir- is for spirea and -in is a common suffix for drugs in the 19th century. Bayer co. neutralized the acidity of the salicin (salicylic acid) by acetylating it, making aspirin (asa) Aka blood-thinning due to irreversible binding that prevents the synthesis of prostaglandins involved in platelet aggregation. Prevention of cardiovascular events such as heart attack and stroke. Cox-1 but increase risk of cardiovascular incidents (lack of balance by cox-2 makes patients more susceptible to blood clots). Analgesic: relief of mild to moderate somatic pain. Relief of moderate to severe post-operative pain when combined with opioids or multimodal analgesia. Disrupted carbohydrate metabolism, sweating, vomiting, depressed respiration, acidosis, fever. Inhibition by aspirin affects both cox-1 and 2 irreversibly (due to acetylation of active site)
