PHAR 300 Midterm: PHAR 300 midterm

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Pharmacokinetics = what you do to the drug. Pharmacodynamics = what the drug does to you. Receptors, ion channels, enzyme, immune system, etc. Many ways for the drug to affect body small intestine goes to the liver first pass effect some drugs cannot be administered orally. Parenteral (injection): fast, accurate, and bypasses the liver. Oral (enteral): drug will reach stomach, most will be absorbed in the small intestine. Topical: generally only designed to act on the surface of the skin. Certain highly soluble substances will pass through the skin (e. g. , nicotine) but skin is generally impenetrable. Intraperitoneal, inhalation, rectal (concentration never peaks as high) Selectivity is targeting the specific cell where the drug will exert its desired action. Iodide is very selective (concentrates in the thyroid), while epinephrine is not (adrenergic receptors are found all over the body) Antacids are so non-selective that they don"t even act directly on the cell.