PHAR 562- Midterm Exam Guide - Comprehensive Notes for the exam ( 67 pages long!)

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 562
• Professor: Derek Bowie

Document Summary

Topics: brain organisation, seven distinct functional regions, each region has a network of neurotransmitter pathways, neurotransmitter pathways use individual neurons as their signaling unit, neuronal signaling and networks, neurotransmitters act directly or indirectly at individual synapses. Integration of excitatory and inhibitory activity determines network behaviour. Neurotransmitters: excitatory neurotransmitters, amino acids: glutamate, aspartate, serine, biogenic amines: dopamine, noradrenaline, serotonin, histamine, choline derivative: acetylcholine. Neuropeptides: modulate many different functions: analgesia, reward, food intake, metabolism, reproduction, social behaviours, learning and memory, usually act at gpcrs, one example is substance p, which is highly involved in pain. Neuronal signaling and networks: neuronal cell types: unipolar, bipolar, multipolar, glial cells: oligodendrocytes, schwann cells, astrocytes. Cns disorders: multifactorial (genetic, epigenetic, environment, neuronal signaling, disease is managed by treating the symptom, no cures available, (cid:862)magi(cid:272) (cid:271)ullet(cid:863) strategy is i(cid:374)appropriate, future success will require better, diagnostic criteria, fuller understanding of pathology. Rett"s sy(cid:374)dro(cid:373)e: neurological disorder affecting mostly girls due to a mutation in mepc2 on the x chromosome.