PHAR 562- Final Exam Guide - Comprehensive Notes for the exam ( 261 pages long!)

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 562
• Professor: Derek Bowie

Document Summary

Topics: brain organisation, seven distinct functional regions, each region has a network of neurotransmitter pathways, neurotransmitter pathways use individual neurons as their signaling unit, neuronal signaling and networks, neurotransmitters act directly or indirectly at individual synapses. Integration of excitatory and inhibitory activity determines network behaviour. Neurotransmitters: excitatory neurotransmitters, amino acids: glutamate, aspartate, serine, biogenic amines: dopamine, noradrenaline, serotonin, histamine, choline derivative: acetylcholine. Neuropeptides: modulate many different functions: analgesia, reward, food intake, metabolism, reproduction, social behaviours, learning and memory, usually act at gpcrs, one example is substance p, which is highly involved in pain. Neuronal signaling and networks: neuronal cell types: unipolar, bipolar, multipolar, glial cells: oligodendrocytes, schwann cells, astrocytes. Phar 562 lecture 1: overview i (09/08/2017) Neuroanatomy: this is not a neuroanatomy class but it is important to have a sense of the different neurotransmitter (nt) systems in the brain. Neuronal signaling and networks: nts act directly or indirectly at individual synapses, direct = affects r proteins.