BIOCHEM 2EE3 Study Guide - Final Guide: Acid Dissociation Constant, Chymotrypsin, Rings Of Saturn

• School: McMaster University
• Department: Biochemistry
• Course: BIOCHEM 2EE3
• Professor: D R.Vuluv

Document Summary

Catalysts are substances that increases rate of reaction (not consumed) Enzymes are proteins: rna can demonstrate catalytic properties. This course we are focusing on protein catalysts. Most biomolecules have functional groups that can react with each other. Same catalyst can be used in multiple pathways - but are highly speci ed. Rates of uncatalyzed reactions is low (not zero) - which prevents them from interacting with each other. Are speci c to their substrates and products. Lyases: group elimination to form double bonds. But in the examples we look at they are larger sometimes. Binding site for substrate inside of pocket on protein. Geometric complimentary to shape of the binding site. Amino acid resides are arranged to favour h-bonding (called electronic/chemical complementarity) If substrate has a donor of hydrogen - then somewhere there should be acceptor. If substrate has hydrophobic group then the surface of enzyme then should have hydrophobic group.