BIOLOGY 2C03 Study Guide - Final Guide: Spliceosome, Meiosis, Corepressor
21 Nov 2017
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Document Summary
Transcriptional changes in chromosome structure e. g. histone modi cations, nucleosome position, epigenetic transcription factors, enhancers and activating proteins, silencers and repressors. Rna transport mrna stability and degradation silencing rnas. Epigenetic modulation make changes to nucleosomal histones a repressor complex contains three components: a dna binding subunit, a corepressor, and a histone deacetylase this makes dna more compacted to transcription cannot occur remember methylation silences the gene! Nuclear receptor: a group of transcriptional factors that, through ligand binding, drive adaptive gene responses to changes in nutritional, environmental, developmental, pathophysiological, and endocrine conditions ligands for nuclear receptors: steroid hormones and lipophilic ligands (fatty acids, cholesterol, bile acids) Capping 5" mrna addition of methylaguanosine protect mrna facilitate transport to cytoplasm facilitate intron splicing orient the ribosome on mrna. Rna splicing: important of maintaining the reading frame spliced @ wrong location can result in a frameshift mutation.
