BIOLOGY 2A03 Study Guide - Final Guide: Renal Function, Afferent Arterioles, Efferent Arteriole

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The 4 main forces that determine gfp are: Glomerular capillary hydrostatic pressure favours filtration and is equal to the blood pressure in the glomerulus. Bowman"s capsule osmotic pressure favours filtration and is due to the presence of non- permeating proteins. Gc= 29 mmhggfp = (pgc+ bp) (pbc+ gc) = (60 + 0) (29 + 15) = 16 mmhg under normal conditions. Gfr can be altered via changes in efferent and afferent arteriolar radii: Constriction/dilation of these arterioles directly alters pgc, which is the largest determinant of gfr: constrict afferent arteriole or dilate efferent arteriole = gfr, dilate afferent arteriole or constrict efferent arteriole = gfr. Gfr can be controlled intrinsically (myogenic response; 18. 11 ) An increase in map leads to stretching of the afferent arteriole: a compensatory response to this stretching is vasoconstriction leads to an increase in resistance of the afferent arteriole pgc= gfr.

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