[BIOLOGY 3UU3] - Final Exam Guide - Comprehensive Notes for the exam (165 pages long!)
29 Nov 2016
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Growth hormone axis (gha) and the stress hormone axis (sha) Underlying this theory was his recognition that the pro- inflammatory somatotropin axis (=growth hormone) was counter-balanced by the stress hormone axis (which was anti-inflammatory. Gh secretion occurs in strong pulses in early sleep associated with slow-wave brain waves. Sleep deprivation suppresses gh secretion as it involves activation of the counter- regulatory sha. Insulin-like growth factor (igf-1), liver, doesn"t show strong circadian rhythmicity, 3 binding proteins igfbp) upregulates its activity in early sleep via regulation of igfbps, a second igf protein (igf-2) allows some specialization in gha impacts. Growth hormone releasing hormone (ghrh) may upregulate sleep. Somatostatin (or somatotropin release-inhibiting factor (srif)) appears inhibitory, but may also promote rems at some doses. Sleep deprivation increases mrna for srif and ghrh. Igf-1 and the stomach hormone ghrelin (grl) may also induce sleep. Ghrelin to sleep is complex, appears to stimulate slow wave sleep. Sleep deprivation elevates ghrelin and reduces fat hormone leptin.
