HTHSCI 1LL3 Midterm: Biochemistry midterm review
9 Mar 2017
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Document Summary
Fluid compartments: most of the body water is intracellular (25l) and the least amount being extracellular (15l). in the extracellular fluid 10l is interstitial, and 5l is blood. Is a measure of the acidity or alkalinity of a solution: ph=-log[h+, ph in the blood must be maintained in a narrow range. Henderson-hasselbalch equation: ph= pka + log [a-]/[ha, when the ph=pka, 50% of the acid is dissociated. This is when a buffer is most effective, although it is still useful to + or 1 ph unit of the pka. Anion gap acidosis: the anions that are usually measured are chloride and bicarbonate. Sodium is the measured cation, so : na+ -(cl + hco3-), 9-15 mmol/l is normal, if larger difference then there is an anion gap (unaccounted for anions, such as ketone bodies in dka) Mudpiles : methanol, uremia, dka (diabetic ketoacidosis, paraldehyde. Respiratory and metabolic causes of ph imbalance: metabolic acidosis.
