HTHSCI 2C06 Study Guide - Final Guide: Catecholamine, Lifesaving, Menopause

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Alarm stage characterized by a general stimulation of the sns and hpa axis, resulting in the release of catecholamine"s and cortisol. Resistance stage the body selects the most effective and economic channels of defense, cortisol levels drop. Exhaustion stage resources are deplted and signs of wear and tear appear. Hpa axis responsible for the adaptation component of the stress response. When crf binds to crf receptors on the anterior pituitary gland, adrenocorticotropic hormone (acth) is released. Acth bound to receptors on the adrenal cortex, stimulating the adrenal release of cortisol. At a certain blood concentration of cortisol, cortisol exerts negative feedback to the hypothalamic release of crf and the pituitary release of acth, and systemic homeostasis returns. Decrease in insulin release & increase in glucagon release, resulting in increased glycogenolysis, gluconeogenesis, lipolysis, proteolysis, and decreased glucose uptake by the peripheral tissues. Stimulates acth release from the anterior pituitary and increased activity of neurons in locus ceruleus.

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