KINESIOL 4SS3 Study Guide - Midterm Guide: Lean Body Mass, Rhesus Macaque, Antagonistic Pleiotropy Hypothesis
19 Sep 2016
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Document Summary
Caloric restriction reduces age-related and all cause mortality in rhesus monkeys. Caloric restriction w/o mal increases longevity and delays onset of age-related disorders. Short lived species (unicellular organisms to lab rats) Value of cr as a tool depends on how it translates to humans. Based ~30% restricted diet since young adulthood. Over past 20 years, data has been generated to support the concept that cr improves health in these monkeys. Most robust intervention to delay aging in diverse species. University of maryland: 2. 6 fold increase in risk of death in non cr animals, based on 109 animals eating whenever they wanted (some diabetic and insulin resistant) and on 8 animals on cr. University of wisconsin: adult onset rhesus monkey cr involved 76 animals, 2. 9 fold increase risk of disease and 3 fold increased risk of death on control animals. National institute of aging (nia: no significant improvement in health and no significant increase in survival.
