LIFESCI 2A03 Study Guide - Midterm Guide: Asymmetric Cell Division, Blastema, Adult Stem Cell
26 Nov 2013
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Document Summary
Adult stem cells cells that can divide to create two cells (another stem cell or differentiated cell) Asymmetric cell division two daughter cells are different from one another (one stem cell and a progenitor cell with limited self-renewal. Symmetric cell division two identical daughter cells are created (both stem cells) potential: maintains homeostasis; balance between stem cells and undifferentiated cells. Intrinsic fate determinants asymmetric localization of components within the dividing cell that results in their differential segregation (one cell has determinants, other does not) Stem cell niche microenvironment that maintains stem cell identity. Adult stem cell categories i) somatic stem cells (go on to create or replenish body cells) ii) asc (create germline cells; sperm and egg) Gsc remains in niche; retains stem cell identity. Spectrosome while in niche (in gsc); fusome when leaves niche, grows (cb; cyst: gsc and cb differ in intrinsic and extrinsic factors that determine identity.
