LIFESCI 2C03 Midterm: LIFE SCI 2C03 Midterm: LIFE SCI 2C03/2CC3 Midterm: Test 2 Review
3 Dec 2015
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Small molecule neurotransmitters: elicit fast synaptic responses: precursors synthesized in cell body are transported via slow axonal transport to the nerve terminal which are taken up by transporters found in the plasma membrane, enzymes synthesize nt in the cytoplasm of the terminal and are loaded into synaptic vesicles via transporters in the vesicular membrane (transporters differ per nt, stored in small clear core vesicles. The action of a nt is to drive the postsynaptic membrane potential toward erev for the particular ion channel being activated: nt binding to postsynaptic receptors causes a postsynaptic conductance change, ion channels open increase conductance, ion channels close decrease conductance, conductance change generates an electrical current called the psc or epc, the psc causes the membrane potential to produce a psp or epp, psp is depolarizing if erev > vm, psp is hyperpolarizing if erev < vm.
