LIFESCI 3A03 Study Guide - Basophil, Megacolon, Endothelium

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Chagas: chronic systemic parasitic infection caused by protozoan trypanosoma cruzi. Kissing bugs draw blood from humans and then defecate feces containing protozoan near the wound, humans scratch the area rubbing protozoan feces into wound. Bugs attracted to areas of co2 (mouth, eyes). Trypanosoma cruzi prevalent in south america (15-20 million affected (15,000 chagas deaths in north america)). There can be a dormant state where no symptoms present but transmission still possible. Because of global warming transmission to north america more likely. 5 instar stages before adult female and 2 instar stages before adult male. All stages can carry and transmit parasite. Probability that hematophagous insects infected with t. cruzi increases with number of bloodmeals and instar. T. cruzi resides in intestinal tract and does not affect insects. Contact through feces of an infected hematophagous kissing bug: feces is liquefied and left near wound, rubbed into wound as human scratches area. Contaminated blood products (transfusions) an organ transplants.

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