MOLBIOL 4P03 Study Guide - Midterm Guide: Enterobacter, Dna Gyrase, Brucella
10 Apr 2017
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Described by prevalence, fatality and the number of anti-fungal drugs sold. 10 million/yr; population susceptible to opportunistic fungal infections. Penetrate sterile body sites; most are opportunistic; global distribution pattern invading pathogens in the cns are very difficult to treat. Sale of antifungal drugs: us . 4 billion increases 20% annually, rising incidence and costs = aging population, increasing populations of immunocompromised individuals. Hyphal tips release enzymes to soften and digest materials for ingestion into the hyphae: main structural differences between fungal and mammalian cells ** targets for antifungal drugs. Cell wall (cellulose, chitin, beta-glucan); sterol in plasma membrane (ergosterol: types of fungal diseases, allergies. Chronic exposure to antigenic component generates immune response oversensitization i. e. cheese and beer industries: toxins (i. e. amatoxins, psilocybin, aflatoxin, mycosis (diseases caused by fungi not due to secretion or cellular properties that induce immune response) Classified based on body areas superficial (no penetration), cutaneous (superficial tissue layers), subcutaneous (asymptomatic), systemic (blood and csf)
