MOLBIOL 3II3 Study Guide - Final Guide: Dna Demethylation, Pancreatic Cancer, Twin
24 Apr 2017
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Epigenome made of chemical compounds and proteins that attach to dna and direct action to control production of proteins. Epigenetics study of change in gene function that are mitotically and/or meiotically heritable and do not entail change in dna sequence. Small or minor worker = scouting and foraging for food, and take care of young. Transcriptome analysis showed differences in gene expression in the brains of minor. Larger or major worker = defend and act as soldier. Learning and memory depends on creb tf and cbp co-activator (hat) and major ants. Hdaci and sirnas for rpd3 hdac enhanced foraging. Measured with assay to monitor movement toward sugar. Foraging is a gain of function supressed by hati. Pioneer transcription factors can be used to reprogram cells. Induced cardiomyocytes express cardiac genes and display sarcomere organization. These reprogrammed fibroblasts express muscle specific alpha actin. Causes lipid vesicles to accumulate in fibroblasts.
