PSYCH 2NF3 Study Guide - Midterm Guide: Synaptobrevin, Cyclic Adenosine Monophosphate, Macrophage

• School: McMaster University
• Department: Psychology
• Course: PSYCH 2NF3
• Professor: Gautam Ullal

Document Summary

Amyloid-precursor protein (app) transmembrane protein important for normal development and plasticity of synapse. 2013: cleaved by secretases; nh2------- ---- -- | -- - | ----- cooh. Amyloid peptide (a ) toxic and detrimental to dendrites, axons and synapse; coupled and cleavage cytoplasm. Neurofibrillary tangles (abnormal helical precipitates; tau-aggregates) formed inside axon. Risk factors for ad: age risk increases with each decade of adult life; 20-40% of >85 years have ad. Late onset and sporadic ad 95% of cases. Apolipoprotein e important for cholesterol transport, maintaining synaptic function, clearing amyloid deposits and neurofibrillary tangles (sporadic = no clear pattern of incidence; here-and-there) Apo e4 variant apolipoprotein e allele; associated with increased risk of amyloid deposits; toxic; associated with late-onset and sporadic ad. Family history of ad: head injury, gender (females more prone) Tau-aggregation (tangles beta-amyloid plaques: taupathy in polymodal areas sensitive to beta-amyloid plaques beta-amyloid in polymodal areas enter taupathy.