[BIOL 4010] - Final Exam Guide - Ultimate 29 pages long Study Guide!

• School: Memorial University
• Department: Biology
• Course: BIOL 4010
• Professor: Andrew Lang

Document Summary

+ssrna genome (has a very specific folded structure when inside the virus particle. Rna dependent polymerase & 4 host proteins required for replication. Repli(cid:272)ase (cid:271)i(cid:374)ds to (cid:1007)" e(cid:374)d a(cid:374)d protei(cid:374) (cid:1005) (cid:271)i(cid:374)ds to (cid:272)oat protei(cid:374) start gene to block ribosome binding. Protein synthesis controlled by secondary structure of rna. Coat start codon always free for ribosome binding. Ribosome binding site for lysis and replicase are blocked by folding. Once ribosome codes coat gene it disrupts folding and allows for opportunity of ribosome binding to the replicase start codon (1 in 20) Once ribosome reached coat termination sequenc, sometimes continues down rna to lysis start codon (1 in 20) Maturation (a) protein is always blocked in a fully formed rna molecule so can only be coded by ribosome while being synthesized (since folding has(cid:374)"t o(cid:272)(cid:272)urred yet) Coat protein is produced much more than other 3 proteins which are produced equally. Contains rna dp rna polymerase in its capsid.