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BCHM 316 Study Guide - Quiz Guide: Isocitrate Dehydrogenase, Malate Dehydrogenase, Succinate Dehydrogenase

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coppermosquito74
11 Feb 2018
School
Queen's University
Department
Biochemistry
Course
BCHM 316
Professor
Glenville Jones

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Document Summary

Isocitrate dehydrogenase: citrate synthase: adds oxaloacetate to acetyl- coa, aconitase. 3: alpha-ketoglutarate dehydrogenase, succinyl- coa synthetase (makes gtp) or atp, succinate dehydrogenase, fumarase, malate dehydrogenase. Remember this conversion: 4 protons = 1 atp generated! Nadh is produced early in the pathway; there are a total of 10 protons pumped ! Therefore using the conversion : we get 2. 5 atp generated from nadh. Fadh2 is generated during step 6 where succinate becomes fumarate! With fadh2, there are a total of 6 protons pumped! Nadh is generated in three steps. (3,4,and 8) : this allows 2. 5 atp to be generated. During the dehydrogenation steps , nadh and fadh2 are produced! There are 20 net atp generated in the cac! In total, with cac,glycolysis, and etc-- we get 30-32 atp generated! Keep in mind that this is under ideal conditions in the perfect world! These energy molecules (nadh and fadh2) power proton transfer/ release. Fun fact: cancer cells ignore the citric acid cycle.

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Related Questions

The complete conversion of a molecule glucose to six molecules of carbon dioxide via glycolysis and the Krebs cycle requires 19 reactions. Put the reactions that are given below in the proper order, beginning with the phosphorylation of glucose to form glucose-6-phosphate and ending with the oxidation of malate to form oxaloacetic acid.

1) 1,3-bisphosphoglycerate + ADP --> 3-phosphoglycerate + ATP
2) fumarate + H2O --> malate
3) isocitrate + NAD+ --> alpha-ketoglutarate + NADH + H+ + CO2
4) phosphoenol pyruvate + ADP --> pyruvate + ATP
5) Succinyl-CoA + GDP + Pi --> succinate + GTP + CoASH
6) glyceraldehyde 3-phosphate + NAD+ + Pi --> 1,3-bisphosphoglycerate + NADH + H+

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5. Almost all of the oxygen (O2) one consumes in breathing is converted to: a. acetyl-CoA. b. carbon dioxide (CO2). c. carbon monoxide and then to carbon dioxide. d. none of the above. e. water.

6. A new compound isolated from mitochondria is claimed to represent a previously unrecognized carrier in the electron transfer chain. It is given the name coenzyme Z. Which line of evidence do you feel is the least conclusive in assigning this compound a position in the electron transfer chain? a. Alternate oxidation and reduction of the mitochondrion-bound coenzyme Z can be readily demonstrated. b. Removal of coenzyme Z from the mitochondria results in a decreased rate of oxygen consumption. c. The rate of oxidation and reduction of mitochondrion-bound coenzyme is of the same order of magnitude as the overall rate of electron transfer in mitochondria as measured by oxygen consumption. d. The reduction potential of Z is between that of two compounds known to participate in the electron transport chain e. When added to a mitochondrial suspension, coenzyme Z is taken up very rapidly and specifically by the mitochondria.

7. Which of the following is not true of the citric acid cycle? a. All enzymes of the cycle are located in the cytoplasm, except succinate dehydrogenase, which is bound to the inner mitochondrial membrane. b. In the presence of malonate, one would expect succinate to accumulate. c. Oxaloacetate is used as a substrate but is not consumed in the cycle. d. Succinate dehydrogenase channels electrons directly into the electron transfer chain. e. The condensing enzyme is subject to allosteric regulation by ATP and NADH.

8. Conversion of 1 mol of acetyl-CoA to 2 mol of CO2 and CoA via the citric acid cycle results in the net production of: a. 1 mol of citrate. b. 1 mol of FADH2. c. 1 mol of NADH. d. 1 mol of oxaloacetate. e. 7 mol of ATP.