Study Guides (390,000)
CA (150,000)
Queen's (5,000)
BCHM (50)
Quiz

BCHM 316 Study Guide - Quiz Guide: Tyrosine Kinase, Insulin Receptor, Tyrosine


Department
Biochemistry
Course Code
BCHM 316
Professor
Glenville Jones
Study Guide
Quiz

This preview shows half of the first page. to view the full 2 pages of the document.
Growth factor, receptors, receptor tyrosine kinases
serine/ threonine kinases: intracellular
Tyrosine kinases inside the cell, binding domain on the outside
hormone/ growth factor binding → effect on cytoplasmic tail
Protein kinase phosphorylates tyrosine residues on tail
Phosphorylated tyrosine attracts other proteins
Concentrated in lipid rafts ( lots of cholesterol and sphingolipids) -
signalling
Arrangement of domains→ receptor specificity for hormone
Insulin receptor is a dimer
All receptor tyrosine kinases have tyrosine, kinase domain
Outside of insulin receptor: cysteine- like domains
1. Growth factor binding
2. Dimerization
3. Phosphorylate each other
4. Activate adaptor protein (has SH2 domains)
find more resources at oneclass.com
find more resources at oneclass.com
You're Reading a Preview

Unlock to view full version