CHEM 281 Study Guide - Final Guide: Thionyl Chloride, Geminal, Isopropyl Alcohol

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23 Mar 2018
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Base (e- pair donors, -ve charge on an atom, nucleophile) attacks acid (e- pair acceptors, +ve charge on an atom, electrophile) Stereoselective synthesis: cis/syn addition, catalyst delivers atoms to same side of molecule. Hydrogenation of alkene: add h2 via catalyst to same side heterogeneous catalysis: catalyst is an insoluble comp of the rx, ex. Pd, ni homogeneous catalysis: catalyst is soluble in the rx medium/solvent, e(cid:454). If no bonds are broken to chirality center the groups will have the same config. Al(cid:449)a(cid:455)s (cid:373)ake sure the priorities ha(cid:448)e(cid:374)(cid:859)t (cid:272)ha(cid:374)ged thru the r(cid:454) Can have atoms other than c at chiral center. Relative config: if two comp have 3 groups in the same config, only one group differs. Dehydration: forms an alkene when heated w strong acid need more conc acid and higher temp for 1 alcohol, lower for 2 and 3. Hx, pbr3, socl2 change oh into a good lg. Socl2 is usually done with pyridine, weak base to promote rx.