KNPE 225 Study Guide - Quiz Guide: Afferent Arterioles, Macula Densa, Distal Convoluted Tubule

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20% of plasma entering glomerulus is filtered, while 80% of plasma leaves through efferent arteriole. Increase in gfr; decrease in blood volume: vasodilation of afferent arteriole increases gfr; vasodilation decreased gfr. Increase in tr; increase in blood volume: passive reabsorption occurs in proximal tubule, controlled reabsorption occurs in distal tubule and collecting ducts. Na+ is passively transported from lumen of prox. tubule into proximal tubular cell. Active transportation from prox. tubular cell into interstitial fluid. Hydrostatic pressure gradient continues flow of sodium into blood stream. ~65% of water is passively reabsorbed by the end of proximal tubule due to osmotic gradient created by na+ transport. Barriers for na+ reabsorption: luminal cell membrane, cytosol, basolateral cell membrane, interstitial fluid, capillary wall. Myogenic mechanism: afferent arteriole constricts in response to increase arteriole pressure, decreases afferent arteriole conductance, not related to compensation of chronic disturbances to blood pressure. Only used in transient fluctuations of blood pressure.

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