MICR 221 Study Guide - Final Guide: Oncolytic Virus, Varicella Zoster Virus, Nuclear Pore

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 221
• Professor: Banfield, Majury, Walker

Document Summary

Diseases attachment penetration uncoating gene expression gene replication assembly extra. Some dna and associated proteins are released into the core and then move to the cytoplasm. Gaps are fixed to make closed circular genome in nucleus via virion dna polymerase. Host rna dependant rna polymerase used to create + rna and mrna. Viral reverse transcriptase converts + rna to ds dna. Envelope proteins in endoplasmic reticulum which add onto viral progeny. Chronic/persistent or latent infection diseases attachment penetration uncoating gene expression gene replication assembly extra. Glycoproteins gb and gc on hsv bind to cell surface proteoglycans (heparan sulfate) Gd on hsv binds to tnf/ngf-family protein receptor. Circularization of genome and transcription of immediate-early genes. Protei(cid:374)s fro(cid:373) ie ge(cid:374)es stimulate transcription of early genes. Protei(cid:374)s fro(cid:373) e ge(cid:374)es fu(cid:374)(cid:272)tio(cid:374)s i(cid:374) dna repli(cid:272)atio(cid:374) to produ(cid:272)e (cid:272)o(cid:374)(cid:272)ata(cid:373)ers (cid:894)(cid:373)ultiple of genome linked end to end) Protei(cid:374)s fro(cid:373) l ge(cid:374)es parti(cid:272)ipate i(cid:374) (cid:448)irio(cid:374) asse(cid:373)(cid:271)ly. Intracellular assembly but maturation linked with egress from call.