PATH 310 Study Guide - Midterm Guide: Deep Vein Thrombosis, Low Molecular Weight Heparin, Venous Thrombosis

• School: Queen's University
• Department: Pathology and Molecular Medicine
• Course: PATH 310
• Professor: Christine Hough

Document Summary

Etiology: cause, or set of causes, of a disease or condition. Coagulopathy: (cid:272)o(cid:374)ditio(cid:374) (cid:449)here (cid:271)lood"s a(cid:271)ility to for(cid:373) (cid:272)lots (or coagulate) is impaired. Thrombosis: pathological process with formation of blood clot (thrombus) in an uninjured vessel (cause of sudden death) Bleeding diathesis: tendency towards prolonged or excessive bleeding. Fibrinolysis: enzymatic break down of fibrin, or fibrin clot. Pro-coagulant: activators of coagulation promote conversion of prothrombin to thrombin, i. e. platelet activation and endothelial damage. Anticoagulant: inhibitors of coagulation fibrinolytic factors, anticoagulant factors, and the endothelium itself. Hemostasis: normal process that stops bleeding after vessel injury with formation of a hemostatic plug (rapid and controlled) Secondary hemostasis: with larger damage, plug is not strong enough, so fibrin clot formation occurs (amplification of the initial response, clotting factors circulate as zymogens and are activated by proteolysis, soluble fibrinogen is transformed into insoluble fibrin)