PHAR 230 Study Guide - Final Guide: Peptic Ulcer, Sucralfate, Cimetidine

• School: Queen's University
• Department: Pharmacology and Toxicology
• Course: PHAR 230
• Professor: Hisham Elbatarny

Document Summary

Mechanism of action/ description adverse effects: mag preps: diarrhea, al & ca: constipation (better to use al + mag) Sys alkalosis: long-term use may mask underlying disease low (<3%, headache, confusion, depression (cimetidine crosses bbb) impotence and gynecomastia (cimetidine, diarrhea, cramps, jaundice, pneumonia, diarrhea, headache, abdominal pain (1-5%) Anti-ulcer: peptic ulcer, gastritis, gastric hyperacidity, heartburn (often. Three forms available: al, mag, or ca based salts carbonate, hydroxides, or. Neutralize acid, reduce irritation of stomach lining and assoc pain (rapid relief, short-lived action) Block h2 receptors reversibly on parietal cells: reduces acid and relieves symptoms. Anti-ulcer (most effective for acid suppression: gerd, ulcers, zollinger ellison erosive esophagitis. Binds irreversibly to pump (atpase) to block acid secretion. Given 1hr before meals (absorption decreased by food and proton pump must be secreting acid for drug to work) Sucralfate: cyto-protective (protects ulcer bed from corrosive action of pepsin: not that effective give on empty stomach. Nsaid analgesic: mid-mod antipyretic antiplatelet anti-inflammatory (high doses)