PHGY 214- Final Exam Guide - Comprehensive Notes for the exam ( 34 pages long!)
30 Nov 2017
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Sherwood (3rd cdn ed. : 248 - 258. Sherwood (2nd cdn ed: 251 262l. Muscle composition muscle (+ connective tissue, nerves, blood vessels) composed of : fascicles = composed of: muscle cells = muscle fibres. One free end at centre of sarcomere. Myosin - two heavy chains coil to form a head and a tail two light chains attach to head. Bundles of myosin molecules form thick filaments form cross-bridges = actin. Titin - large elastic molecule which attaches myosin to z-disk function : On contraction, as z disks move closer: Energy used to change angle of myosin head. Sliding filament steps: myosin head bound to actin (no atp) this step is called. Atp binds to head which releases the actin. Atp hydrolysis; free myosin head swings, grabs a new actin molecule. Pi released, myosin pulls actin towards centre of sarcomere this step is called. Adp released, myosin remains bound to actin (= step 1) terminated by.
