HSM 330 Study Guide - Subfornical Organ, Lamina Terminalis, Orexigenic

• School: Ryerson University
• Department: Health Services Management
• Course: HSM 330
• Professor: Daolun Chen

Document Summary

Dipsogenic stimuli exert their actions through neurons in outer shell of subfornical organ. All 3 parts of the lamina terminalis form direct neural connections to the lha. Site of both short term and long term systems. Produces npy & agrp, which stimulate appetite. Leptin was the first one to organ to stimulate drinking be discovered. Increase leptin, decrease administered into cerebral ventricles. Pyy-appetite suppressant, acts on arcuate nucleus to inhibit npy/agrp, and stimulates pomc cells. Cck- peptide hormone released by intestine, satiety hormone. Scd-1- is found in liver, can protect obesity in mice by inactivating scd-1 gene. Ptp1b inhibits leptin and insulin signalling in the hypothalamus. Proteins degeneration of the aging nervous system. Trpv-4 expressed in subfornical organ + ovlt. C-fos, a protein that is released by neurons when they fire aps. Hyperdipsia abnormally high water intake in order to correct a fluid deficit. Prader willi syndrome- inherited condition that results in extreme obesity.