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Biological Sciences
BISC 101
Derek Bingham

#3 – CALCIUM’S ROUTE FROM THE INTESTINES TO THE TRICEPS + CALCIUM’S ROLE IN MUSCLE CONTRACTION AND RELAXATION + CALCIUM’S ROLE IN BONE GROWTH OF THE HUMERUS CALCIUM’S ROUTE: 1. Absorbs into intestine  intestinal capillaries  venules  veins 2. Through veins  inferior vena cava  right atrium 3. Through tricuspid valve into right ventricle 4. Heart contracts, blood goes through pulmonary valve, 5. into pulmonary trunk 6. Blood goes through pulmonary arteries into the lungs 7. Pulmonary arteries  arterioles  pulmonary capillaries (where external respiration occurs) 8. Blood is now oxygenated in pulmonary capillaries  venules  pulmonary veins 9. Blood returns to left atrium 10. Goes through bicuspid valve into left ventricle 11. Heart contraction pushes blood through aortic valve into aorta 12. Blood goes into right or left subclavian artery  axillary artery  brachial arteries 13. Brachial artery brings oxygenated blood with calcium into the triceps 14. Brachial artery  arterioles  capillaries then bring nutrients to the tissue cells ROLE IN MUSCLE CONTRACTION: 1. At rest: a. Myosin-binding sites on actin are blocked by tropomyosin b. Tropomyosin is held by troponin (latch-lock) 2. Action potential (AP) spreads rapidly throughout sarcoplasm via transverse tubules (T-tubules) 3. Sarcoplasmic reticulum (SR) becomes depolarized due to arrival of AP via T-tubules 4. Ca2+ released into sarcoplasm 2+ 5. Ca ions bind to troponin  troponin changes shape  releases hold on tropomyosin which moves out of position and ex
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