BISC 101 Study Guide - Final Guide: Voltage-Gated Potassium Channel, Cell Membrane, Neuroglia

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pinktiger219

11 Dec 2017

School

Simon Fraser University

Department

Biological Sciences

Course

BISC 101

Professor

Tony Williams

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Document Summary

No; but communicate with & modulate signals from nerve cells & modulate synapse function: define and explain a membrane potential. [gradients] exist across the membrane: describe the formation or resting membrane potential & the role of ion channels & Outward diffusion k+ ions via open resting k channels. Little inward diffusion of na+ due to few na channels open. Voltage gated na+ channels open which results in an increase in na permeability. Voltage gated k+ channels open which results in an increased k+ permeability. K+ flows out & channels stay open longer than na+ channels re (hyper) polarization: describe the 5 phases of an action potential. Further depolarization allows increased amount of na+ inside cell. If depolarization reaches threshold all voltage gated na+ channels open. = reflux of na+ into cell (+ feedback) Stays open longer than na+ channels therefore goes hyperpolarization. Na channels behind action potential site = inactive. Axon diameter: describe & explain the importance of myelinated axons.

Related Questions

Why do ion channels not function like open pores?

What is membrane potential?

How do K⁺ leak channels work? Why is the membrane potential of a resting cell negative?

What is patch clamp recording? What is one of the major insights gained from patch clamp reporting experiments?

Compare and contrast the three types of gated ion channels.

Be familiar with the different parts of a neuron.

During an action potential, what happens to the membrane potential, voltage-gated Na⁺ channels, Na⁺ ions, voltage gated K⁺ channels, K⁺ ions, and Na⁺-K⁺ ion pumps?

When an action potential reaches a synapse, what happens to the Ca²⁺ channels, Ca²⁺ ions, neurotransmitters, transmitter-gated ion channels, and the post synaptic neuron?

What effect do excitatory or inhibitory neurotransmitters have on postsynaptic cells?

What is an example of a mechanically gated ion channel?

Santiago Ramon y Cajalâs theory of dynamic polarization refers to the:

(a)membrane potential of a neuron at rest.

(b)membrane potential of a neuron firing action potentials.

(c)opening and closing of gated channels in the membrane.

(d)one way flow of information in neurons from dendrites to axon terminals.

(e)one way flow of information in neurons from axon terminals to dendrites.

Over the course of scientific history, there are many examples of scientists reaching the right conclusion for the wrong reasons. When Schwann first proposed that the nervous system was made of individual cells, he based it on observations of:

(a)synapses.

(b)dendrites

(c)axon terminals.

(d)astrocytes.

(e)Nodes of Ranvier.

The synaptic cleft was finally seen in the 1950s. What prevented scientists from seeing it earlier?

(a)The resolution of the light microscope.

(b)They were looking in the wrong place.

(c)Their tissue was not appropriately stained.

(d)Myelination of the axons.

(e)all of the above

The resting membrane potential of a neuron is approximately:

(a) +65 V

(b) +65 mV

(d) -65 mV

What is largely responsible for the resting membrane potential in a neuron?

(a)Axonal insulation by myelin

(b)Voltage-Gated Sodium Channels

(c)The Action Potential

(d)Potassium Leak Channels

Which of the following would DECREASE the propagation velocity of an action potential down an axon?

(a)Increase in axon diameter

(b)Increase myelination between nodes of Ranvier

(c)Remove myelination between nodes of Ranvier

(d)Decrease density of voltage-gated Na+ channels except at the Nodes of Ranvier

The resting membrane potential of a neuron can be estimated using the:

(a)Nernst equation

(b)Goldman equation

(c)Hodgkin and Huxley equation

(d)Ohmâs law

18. What would happen to the resting membrane potential of a neuron if you added K+ to the extracellular fluid?

(a)Resting membrane potential would increase (become more positive)

(b)Resting membrane potential would decrease (become more negative)

(c)Resting membrane potential would not change

(d)Resting membrane potential would be abolished

. Which of the following statements is FALSE for Graded Potentials

(a)Magnitude changes with magnitude of triggering stimulus

(b)Magnitude decreases with distance from initial site

(c)Cannot be summed

(d)No refractory period

In the nervous system, the strength of the stimulus is coded into:

(a)The frequency of action potentials generated

(b)The amplitude of action potentials generated

(c)Both the frequency and amplitude of action potentials generated

(d)The duration of individual action potentials generated

Ion movement during both the depolarization and repolarization phases of an action potential are the result of:

(a)active transport pumps along the neuron membrane.

(b)diffusion of ions down their electrochemical concentration gradients.

(c)negative feedback loops.

(d)All of the above

At the peak of the action potential, the membrane potential is:

(a)Exactly at the Na+ equilibrium potential

(b)Greater (more positive) than the Na+ equilibrium potential

(c)Above 0 mV but less positive than the Na+ equilibrium potential

(d)0 mV

Tetraethylammonium (TEA) is a drug that blocks voltage-gated potassium channels. What effect would this have on an action potential?

(a)Prevent the rising phase

(b)Prevent the cell from reaching the threshold to trigger an action potential

(c)Prevent or prolong the falling phase

(d)None of the above

The hyperpolarization phase of the action potential is due to:

(a)The opening of voltage-gated Cl- channels

(b)Prolonged opening of voltage gated K+ channels

(c)The closure of resting Na+ channels

(d)Rapid inactivation of voltage-gated K+ channels

The period when it is difficult to initiate another action potential for several milliseconds due to voltage-gated sodium channel inactivation is referred to as the:

(a)Relative refractory period

(b)Absolute refractory period

(c)Resting period

(d)Hyperpolarization period

In the human central nervous system, Gap junctions are found:

(a)Only between neurons

(b)Only between astrocytes

(c)In both neurons and astrocytes

(d)In all cells

Small molecule transmitters such as acetylcholine are synthesized in:

(a)The nerve terminal

B) The cell body and transported to the nerve terminal

C) Synaptic vesicles

D) Endoplasmic reticulum

Prior to Otto Loewiâs classical experiment, which of the following was not known:

(a)stimulation of the vagus nerve slows the heart

(b)extracts of frog heart, made following vagal nerve stimulation, slow the heart

(c)some acetylcholine effects are similar to those produced by muscarine

(d)vagal nerve stimulation releases a substance which slows the heart

Which of the following is most important in determining if neurotransmission is excitatory or inhibitory?

(a)The structure of the synapse

(b)The neurotransmitter released by the presynaptic neuron

(c)The neurotransmitter receptor

(d)The strength of the stimulus

Benzodiazepines such as Valium allosterically regulate GABA receptors by:

(a)Binding at receptor sites other than the transmitter binding site

(b)Binding at the transmitter (GABA) binding site on the receptor

(c)Blocking the action of the endogenous transmitter

(d)Mimicking the action of the endogenous transmitter

GABA-A receptors are ligand-gated Cl- channels. The equilibrium potential of Cl- is -65 mV. At the neuronal resting membrane potential of -65 mV, GABA binding to the GABA-A receptor would result in the opening the Cl- channel, resulting in:

(a)no net flow of Cl- ions

(b)Cl- inflow and hyperpolarization

(c)Cl- outflow and depolarization

(d)Cl- outflow and hyperpolarization

At the mammalian neuromuscular junction, the released neurotransmitter acts on:

(a)muscarinic receptors

(b)nicotinic receptors

(c)adrenergic receptors

(d)Beta receptors

Neurotransmitters are packaged into synaptic vesicles by:

(a)endocytosis following transmitter release

(b)presynaptic membrane transporters

(c)vesicular transporters

(d)all of the above

. Which of the following are NOT types of ion channels?

Voltage-gated

(a)Ligand-gated

(b)G protein coupled receptor (GPCR)-gated

(c)Leak channels

(d)NONE of the above

NMDA receptors are unique in that their ion channel is:

(a)Ligand-gated

(b)Voltage-gated

(c)Ligand- and voltage-gated ion channels

(d)GPCR-gated

. Which of the following is INCORRECT regarding Catecholamine neurotransmitters

(a)Includes Dopamine, Norepinerphrine, and Epinephrine

(b)Contain a Catechol Ring

(c)Synthesized from Tryptophan

(d)Are produced by neurons whose cell bodies are located in the upper brainstem

The largest and most diverse group of receptors in eukaryotes is:

(a)Ligand gated receptors

(b)Glutamate receptors

(c)G-Protein coupled receptors

(d)Allosteric receptors

The most abundant G-protein coupled receptor in the brain is:

(a)Glutamate receptors

(b)Acetylcholine receptors

(c)Cannabinoid receptors

(d)Dopamine receptors

Which of the following drugs DOES NOT block voltage-gated Na+ channels

(a)Lidocaine

(b)Riluzole

(c)Reserpine

(d)Tetrodotoxin

Sarin, a nerve gas, exerts its toxicity by:

(a)blocking nicotinic receptors

(b)inhibiting choline acetyltransferase

(c)inhibiting acetylcholinesterase

(d)inhibiting voltage-gated Na+ channels

Botulinum Toxin (BoTox) interferes with transmitter release by:

(a)cleaving protein(s) involved in transmitter release

(b)blocking voltage-gated Ca2+ channels

(c)blocking voltage-gated Na+ channels

(d)blocking voltage-gated K+ channels

Atropine is:

(a)An agonist of the acetylcholine ionotropic receptor

(b)An antagonist of the acetylcholine ionotropic receptor

(c)An agonist of the acetylcholine metabotropic receptor

(d)An antagonist of the acetylcholine metabotropic receptor

BISC 101 Study Guide - Final Guide: Voltage-Gated Potassium Channel, Cell Membrane, Neuroglia

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