MBB 222 Study Guide - Final Guide: Amylin, Al Amyloidosis, Amyloidosis

• School: Simon Fraser University
• Department: Molec Biol & Biochem
• Course: MBB 222
• Professor: Edgar Young

Document Summary

Misfolding can occur in proteins, which can cause/contribute to the development of serious disease (ex. In the misfolding mechanism: a soluble protein that is normally secreted from the cell, is secreted in a misfolded state and converted into an insoluble extracellular amyloid fiber. These fibers are highly unordered and unbranched. Amyloid deposition is the phenomenon of amyloid fibrils being deposited into the nucleus (thus becoming an amyloid nucleus as there are fibrous extracellular proteinaceous deposits) Diseases caused by misfolding are collectively referred to as amyloidosis. Primary systemic amyloidosis is caused by deposition of fibrils consisting of misfolded immunoglobulin light chains or fragments of light chains derived from proteolytic degradation. U9-08 load islet amyloid polypeptide; type 2 diabetes. Islet amyloid polypeptide is the specific protein fibril that causes type 2 diabetes. U9-08 must amyloid-beta peptide, amyloid-beta precursor protein; alzheimer"s disease. In some amyloid fibers, the overall structure features 2 layers of beta-sheet (amyloid-beta peptide)