MBB 222 Study Guide - Final Guide: Beta-Galactosidase, Tata Box, Transfer Rna

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burgundycoyote951

11 Dec 2016

School

Simon Fraser University

Department

Molec Biol & Biochem

Course

MBB 222

Professor

Edgar Young

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Document Summary

General transcription factors bind to this region. Tata box , ~25-30 bp upstream of transcription start site. Bound by the tata binding protein (tbp), which is part of tfiid. Initiator (inr) sequence spans the start site (+1) and the dna is unwound here. Commonly found ~100-200 bp upstream of the transcription start site of many genes. Includes the ccaat box and often a g-c rich box. Bind specific transcription factors that can influence transcription. Genes that are expressed coordinately (in response to a common signal) typically contain a similar enhancer elements. This is an example of an operon: multiple genes regulated by one promoter. Orientation of an enhancer in the dna is not significant. Eukaryotic rnap cannot bind dna promoters without help of transcription factors, which are proteins. Some tfs bind dna and help rna polymerase bind. Others may assist in protein-protein interactions to enhance transcription. Others may help to recruit coactivators or corepressors.

Related Questions

1 DNA sequences found in introns provide [A] amino acid sequence information.

[B] regulatory information.
[C] no known useful information.

[D] structure for the gene.
[E] alternative DNA splicing possibilities.

3. The TATA box is a(n)
[A] sequence close to the promoter region of many genes.
[B] square-shaped sequence.
[C] enhancer consensus sequence.
[D] activator sequence necessary for proper translation.
[E] None of the above

5. Regarding genes and gene expression, which of the following is not a difference between prokaryotes and eukaryotes
[A] Eukaryotic DNA does not contain a TATA box close to the initiation site as does prokaryotic DNA.

[B] In eukaryotes, RNA polymerase requires

'transcription factors'or initiation.

[C] Prokaryotic genes are often grouped together in

operons.

[D] In eukaryotes, the regulation of several genes at once requires common control elements in each of the genes.
[E] There is a diversity of eukaryotic polymerases that is reflected in the diversity of eukaryotic promoters.

10) In eukaryotic cells, a repressor

[A] is made of DNA.
[B] binds to the enhancer region to block transcription. [

C] is located both upstream and downstream from the promoter.
[D] binds to the operator to block RNA polymerase.

[E] binds to a silencer to reduce transcription rates.

Coordinated regulation of genes in eukaryotic cells [A] is the result of positioning the same regulatory sequence in front of each gene.
[B] results from all of those genes being under the control of one promoter.

[C] occurs because related genes all have the same

operons.
[D] occurs because enhancers cause DNA to bend.

MBB 222 Study Guide - Final Guide: Beta-Galactosidase, Tata Box, Transfer Rna

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