MBB 222 Study Guide - Final Guide: Atp Hydrolysis, Consensus Sequence, Snrnp

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Mbb222 exam vocab definitions: eukaryotic mrna processing and the spliceosome. Eukaryotic pre-mrnas must go through several processing steps before they can be translated and exported out of the nucleus. Mrna that has just been transcribed from the dna transcript and has not undergone any processing in the nucleus. Pre-mrnas are first coated in rna-stabilizing proteins that protect the pre- mrna from degradation while it is processed and exported out of the nucleus. While the pre-mrna is still being synthesized, a 7-methylguanosine cap is added to the 5" end of the growing transcript via a phosphate linkage. This cap protects the nascent mrna from degradation by exonucleases. This is added to the 5" end of pre-mrna. The 7-methylguanosine is linked to the 5"-terminal residue on the mrna via a. This means that no free 5" phosphate group exists in a properly capped mrna.

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