MBB 222 Study Guide - Final Guide: Scleroprotein, Collagen Helix, Coiled Coil

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U9-05 first fibrous protein (vs. globular protein) Fibrous proteins have polypeptide chains arranged in long strands or sheets. Largely based on a single type of secondary structure with a simple tertiary structure. Function: provides support, shape and external protection to vertebrates made of fibrous proteins. All fibrous proteins are insoluble in water (conferred by a high concentration of hydrophobic amino acid residues both in the interior of the protein and on its surface) Globular proteins have polypeptide chains folded into a spherical or globular shape. Often has several types of secondary structure. Function: most enzyme and regulatory proteins are globular proteins. U9-05 first case studies: alpha-keratin, collagen, silk fibroin. These proteins share properties that give strength and/or flexibility to the structures in which they occur. In each case, the fundamental structural unit is a simple repeating element of secondary structure. Alpha-keratin: these proteins have evolved for strength and are found only in mammals.