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Ch 3 Neurophysiology.doc

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Simon Fraser University
PSYC 280
John Reynolds

Ch 3 NeurophysiologyElectrical Signals are the vocab of the nervous systemLiving cells possess electrical charges more negative insideElectricity happens when you think do an action feeling an itch etcA balance of electrochemical forces produces the resting membrane potential of neuronsNeuron contains mostly of protein anionscannot exit the cellIons are dissolved in a intracellular fluid cytoplasm separated from the extracellular fluid by the cell membraneNeuron at rest resting membrane potential 60mVCell membrane is made up of a lipid bilayer 2 layers of fatty molecules where proteins float bw them proteinsion channelIon channel selects some K to cross membrane selective permeabilityResting potential balance bw K inside and outside the neuronDiffusion the force that cause molecules diffuse from a region with highlow concentrationMolecules move down their concentration gradient until evenly distributedElectrostatic pressure distribution of electrical charges not the distribution of moleculesopposite charges attract like charges repelattracted to theinterior of cell viceversaSodiumpotassium pump pumps 3 Na ions out of cell for every 2 K pumped inthis is the energy in brainK ions tend to leave making it more negative inside electrostatic pressure pull K insideequilibriumNernst equation predict voltage needed to counterbalance diffusion force across membrane high intercellular K and high extracellular NaNeurons undergo change in polarization sending electrical signal from one end of its axon to the otherAction potential change in neuronal polarization along axon in high speed movement of Na into cellhow hyperpolarization increase in membrane potential neuron is moreinsidefrom 6070mVdepolarization from 6050mV brings it closer to 0larger depolarization make more action potentials not largelocal potentials electrical potential that is initiated by stimulation at a certain areagraded response that spreads across the membrane decreasing in strength with time and distance
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