IMIN200 Study Guide - Final Guide: Endocytosis, Frameshift Mutation, Lysosome

• School: University of Alberta
• Department: Immunology and Infection
• Course: IMIN200
• Professor: Edan Foley

Document Summary

Lpxf removes the phosphate group (e. coli, b. thetaiotaomicron) Salmonella adds groups - mask the negative charge on the phosphate. One that messes up the acyl change (adds hydroxyl group) has a different purpose. Need to know which molecules activate which tlr. Salmonella modifies lipid a to avoid antimicrobial peptide killing. Arnt - transfers an amino-arabinose sugar (can happen on either phosphate) - masks negative charge. Pagp adds an acyl group and pagl removes an acyl group - mess up interaction with tlr4. Yersinia has different acyl chains at 21 degrees (6 chains) and 37 degrees (4 chains) - avoid tlr4. Pedestal formation in e. coli (epec and ehec) Requirement for t3ss to be activated: coli injects tir and becomes phosphorylated -- can bing to intimin. Noticed that when yersinia was grown on bhi-oxalate, secreted a lot more proteins than usual. Nobody really knows how this is linked to what happens in vivo.