IMIN371 Study Guide - Final Guide: Adaptive Immune System, Antibody, Immunoglobulin A
16 Oct 2016
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Immune system begins to develop around 12 weeks thymus development: earliest that babies can be born is 23 weeks can mount a t cell response. Intrauterine infections: toxoplasmosis, cmv, rubella, varicella, raise adaptive immune response and igm production of the fetus. Transition from intrauterine to neonatal life: skin, orifices, intestine colonized with microbiota within 24-48 hours post-birth, first line of defense in neonates. Chlamydia (eye infection maternal birth channel) Dcs and monocytes low mhc-ii & co-stimulatory molecules. Complement low c9, alternative pathway prevalence. Nks low numbers and functionally ineffective: passive protection. Starts at 13 weeks, no igm/iga (igg) May cause false-positive tests for newborn hiv, hepatitis, etc. (they have the antibodies, but they may not make the antibodies may not have the infection) Live-attenuated vaccination not effective until these maternal antibodies are gone. Not absorbed only effective in digestive tract: block receptors for microbes to enter mucosal epithelium, reduce antigen concentration.
