[IMIN371] - Final Exam Guide - Ultimate 30 pages long Study Guide!

162 views30 pages

Document Summary

Ab (esp. siga) blocks binding of virus to host membrane. Igg, igm opsonize and enhance phagocytosis of viral particles. Complement mediates opsonization (c3b) and lysis of enveloped viral particles (mac) (cid:12254) Ifn- secreted by th/tc cells has direct antiviral activity. Nk cells and macrophages kill infected cells by adcc (cid:12254) Neuraminidase (n) - helps new virus escape host cells. These two proteins have the highest rates of antigenic variation (continually mutating) (cid:12254) Occurs due to high mutation potential of rna genome. Surface proteins change very slightly over time (cid:12254) Occurs when di erent viruses infect a single cell. Rna genome segments can be swapped in new virus. Cause of pandemics (population has no resistance to new combination) (cid:12254) Once we have an e ective immune response, we won"t initiate a new one until the old one is no longer e ective ex. Antibody-mediated mechanisms: extracellular bacteria (cid:12254) (cid:12254) (cid:12254: toxin neutralization, complement-mediated lysis (mac, opsonization/phagocytosis, anaphylatoxins: mast cell degranulation, chemotaxis.