IMIN371 Study Guide - Final Guide: Retrovirus, Inflammation, Primary Effusion Lymphoma
16 Oct 2016
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Present at birth, but not always manifested at birth. Bare lymphocyte syndrome: treat(cid:373)e(cid:374)t of 1 i(cid:373)(cid:373)u(cid:374)odeficie(cid:374)cies. Gene therapy add functional gene to hscs, retroviruses: scid mouse models. B cells cannot get from pro-b cell stage pre-b cell stage. T cells cannot get from dn dp. Isolate bone marrow stem cells from scid mouse and infect with retrovirus that contains rag1 gene. Can reconstitute b and t cells (functionally: problems with gene therapy. Cannot control where the retrovirus integrates may create oncogenes/knock out important tumor suppressors. Not effective for diseases with complex etiology or unknown cause. Secondary immunodeficiencies: non-genetic basis acquired immunodeficiencies, severe malnutrition. Defects in t cell production and function, problems with mucosal barriers, many immune defects. Used to treat inflammatory diseases, autoimmune diseases, organ transplants. Balance of alleviating symptoms vs. susceptibility to infection. Measles impairs ag presentation and production of il-12 by macrophages and dcs. Il-12 activator of nk cells and th1 cells. Hiv severe attenuation of adaptive immunity.
