[IMIN405] - Final Exam Guide - Everything you need to know! (44 pages long)

• School: University of Alberta
• Department: Immunology and Infection
• Course: IMIN405
• Professor: James Stafford

Document Summary

Do not undergo many modifications (non-tcr, non-bcr receptors) The specificity of the response depends on the cell itself. How can a cell use a conserved set of signalling molecules, receptors, and adaptors to generate a large range of responses? (cid:12254) (cid:12254) (cid:12254) (cid:12254) Plasma membrane proteins expressed on the cell surface. Have an agonist - something that the receptor binds to. Once bound/activated, the receptor associates with intracellular effectors - something happens that changes the receptor into its on state. Signal transduction - secondary and tertiary (etc. ) effectors amplify the signal -- signal cascade. The cell can integrate this information into a response. Selected cascades of signalling bias the system towards a specific response. Currencies of intracellular signal transduction (cid:12254) (cid:12254) (cid:12254) (cid:12254) Modification of phospholipids - makes them more attractive to effectors - recruitment to the membrane. Phosphorylation of tyrosine = important in immunoregulation (cid:12254) The tyrosine residue is embedded within a domain.