MMI351 Study Guide - Final Guide: Diphtheria, Cytosol, Anthrax Toxin

• School: University of Alberta
• Department: Medical Microbiology and Immunology
• Course: MMI351
• Professor: Kimberly Ellison

Document Summary

Mmi 351 final exam review - organisms pt. 12 serogroups based on capsular polysaccharide (6 associated with disease) Transmission by respiratory droplets, colonizes the nasopharynx (adheres to non-ciliated epithelial cells) Can transiently invade epithelial cells and transcytose into blood vessels. Meningococcemia (vascular necrosis, inflammation, hemorrhage, petechiae on skin) Children >6 months but <2 years are most susceptible (unable to mount a t-independent response against the capsule) Capsule - main virulence factor, polysaccharide capsule, allows survival in blood, serogroup classification basis. Pili (type iv) - adhesion (loose binding), aggregation, twitching motility, natural competence. Opa and opc - mediate tight binding, bind ceacams and extracellular matrix. Factor h - prevents activation of complement via the alternative pathway. A, b, c, w, x, y = disease-causing (b, c, y prevalent in americas) Serogroup b has ( 2-8)-n-acetylneuraminic acid in the capsule (same type of polysaccharide linkage that we have on our cells - not particularly immunogenic)