MMI436 Study Guide - Midterm Guide: Omega-3 Fatty Acid, Cohort Study, Longitudinal Study

• School: University of Alberta
• Department: Medical Microbiology and Immunology
• Course: MMI436
• Professor: Paige Lacy

Document Summary

Leukocytes: can arm themselves to recognize antigen, polymorphonuclear leukocytes. Histamine: not a major mediator in asthma* Omega 6 polyunsaturated fatty acids mainly give rise to: pro-inflammatory lipid mediators (omega-6: feed into the phospholipid bilayer > arachidante > cleaved . > arachidonic acid > pro-inflammatory effect decreased arachidonic acid, decreased inflammation. Omega 3 fatty acids: resolving impact of inflammation. Ratio of omega 3 : omega 6 > determine rate of inflammation. If we discover a new factor, plus an inhibitor for that factor, that could contribute to inflammatory disease, we need to test this in a clinical study. Prospective- you get to decide the study. Longitudinal- takes over a long period of time. Cohort- to strengthen the study it is randomized and double blinded. No one knows who had the treatment. Control: must take inhibitor placebo pill needs to be identical in shape, size, color Let"s say you discover a potential biomarker in blood samples for disease risk.