Lecture 14: Inhalants
1) Solvent inhalation ( like gasoline etc.) are most prevalent in younger population.
What are some of the reason for this? Highest rate is seen in what type of group?
2) What are some of he inhalant? Are they all structurally similar?
3) Effect on behavior: T/F they are alcohol like? What some of the effects? How
long does the high last? What happen after the high is over?
4) Inhalants: at low level? And why? at high level? T/F high level can lead to coma,
hallucination, and death
5) What are the 4 different organic compounds that are found in these solvent that
are inhaled? Give example of them
6) Toluene: what is another name for toluene? What are its physicaly properties (i.e.
color smell etc)? what products are they usually found in? T/F the lowest abuse
potential of all?
7) Gasoline: what is in gasoline? T/F can contain lead?
8) Administration: what are some of the way? What does it cause usually when
9) Absorption: it gets to the brain very quick why? T/F it leaves as quickly as it gets
in? T/F you don’t need a constant administration? What determines the rate of
diffusion of inhalants? Part of the body receives the most? Least? Why
10)Excretion and metabolism: what happens to the blood concentration if you stop
inhaling? When will inhalant remain in the body for longer? Rate at which
inhalants leave the lung is dependent on what?
11) If not exhaled, what happen to the inhalant? What if it is highly volatile (i.e.
evaporates a lot)? Toluene: T/F is volatile. Where is majority metabolized?
12) Excretion and metabolism: Aromatic hydrocarbon (i.e. toluence): what kind of
metabolites is it converted to in liver? How is it then excreted? T/F aliphatic
hydrocarbon (propane) are unchanged and leave through respiration.
13) Mechanism: does it produce similar effect to alcohol like inhibition? How so?
What happen to GABA and glycine activity? What happen to the NMDA
(especially those with NR1 and NR28 subunits) and