Nicotine II lecture 13
1) What are 4 physiological effect of nicotine? (Hint: a guy in the snow, has wrinkles
and is smoking and say I am not hungry)
2) If you quit smoking what happen to your weight? And why is that? Why is it that
you get respiration rate increase?
3) What are some other associated behaviors with those who smoke?
4) The central effect of nicotine is mediated through what receptor? What does
nicotine act as on this receptor?
5) Ach Receptor structure: how many subunits? Why is it that we have receptor
subtypes? Where does Nicotine bind on this receptor (similar to gaba)? What
happens when nicotine binds to it? How many sites does nicotine have for
binding? Where is it found presynaptic ally (most of them are these)? And where
is found Postsynoptically?
6) Mechanism: when AcH receptor activated in presynaptic what happen?where is
this types of receptor? If postsynaptic what happen? Where is this receptor found?
Which one release NT and what kind? (hint rewarding)
7) Nicotine receptor subtypes function: alpha 4 subunit mutant show what? Beta 2
subunit knockout mouse show what? Antagonist to both alpha 4 and beta 2
subunits what happen? What other subtype are involved?
8) Beta 2 and Alpha 4 are predominant Ach receptor where nicotine binds, where are
they found exactly in mesolimbic system? What happens when Nicotine binds to
9) if you add a single dose of nicotine directly to Presynaptic receptor on dopamine
releasing neuron going from VTA▯NA, what happen to dopamine level in NA?
How long does this effect last? What limbic system it effect?
10) How does nicotine receptor desensitization occur? Can it be activated be agonist
during this time? In a chronic user what happen to the neurotransmitter levels?
11) not all nicotinic receptors desensitize the same way, explain using GABA
receptor ( what subunit specifically, is it susuptible to densensitation), and
glutamate receptor(what subunit specifically, is it susuptible to densensitation?).
What will happen if a neuron in mesolimbic or VTA (controlled by both GABA
and glutamate) was subjected to nicotine?
12)What is the normal function of Ach in muscles?
13) Peripheral effect of nicotine: where exactly are these nicotinic receptors located
in periphery? What happens at low dose? High dose? Why is it bad at high doses
(chemical basis # 10)? How does it increase HR/BP?
14) what is monoamine oxidase e