ANSC 4650 Study Guide - Midterm Guide: Complement Membrane Attack Complex, C5A Receptor, Complement Component 3
21 Oct 2016
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When fresh serum heated at 56 c for 1hr the bactericidal capacity of heat stable antibodies was lost. The complement system an ancient defense mechanism. Horseshoe crab dated to be over 450mya. Contains numerous hemolymph proteins that are homologous to vertebrate complement proteins. = comprised of over 30 different humoral proteins. And by numerous elements of the coagulation and fibrinolytic systems. = comprised of 3 different activation pathways that each lead to the common formation of a mac. That punches holes in microbial cell membranes affecting their ability to osmoregulate and survive. ** gene duplication of c3 lead to c4 and c5. ** gene duplication of bf lead to c2. ** masp gene duplications leading to c1r and c1s. ** also due to complement gene duplication events leading to c6-9. Possess a full set of complement genes = mammals, birds, reptiles, amphibians and fish.
