ANSC 4470 Study Guide - Quiz Guide: Alanine, Gsk-3, Lactalbumin
5 Apr 2016
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Energy balance (lactate 3 co2: + 5 nadh = + 15~p. Energy balance (glucose 6co2: glc 2 lac = + 2~p. 2 lac 6 co2 = + 36~p: = +38~p. Control of the tca cycle: pyruvate dehydrogenase is a muli-enzyme complex requiring thiamin, lipoic acid, pantothenic acid, ribolavin & niacin. Important control because once accoa is formed, gluconeogenesis is not possible. Pdh kinase is part of the pdh complex. 4 pdhk isozymes have been ideniied, pdhk2 & pdhk4 are found in all issues. Pdhk is acivated by high accoa/coa raio & high nadh/nad raio (i. e. oxidaion inhibits pdh) Pdh phosphatase is also part of the pdh complex. 2+, pdp2 in liver is not responsive to ca2: citrate synthase (cs) Inhibiion is very efecive because of low [oaa] Muscle & mammary issues use ketone bodies in mitochondria, so [facoa] is never high enough to inhibit cs. Citrate in cytoplasm used for faty acid synthesis in lipogenic issues (liver, adipose, mammary glands)
