BIOC 3560 Midterm: BIOCHEM Midterm notes
10 Mar 2017
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Document Summary
Chemical structure dictates function of the protein. Size (molecular weight), shape (2 structure, fold), charge (+ve, -ve patches) and hydrophobic/hydrophilic properties are of interest. Looking at the atomic level learn about the structure/function relationship. If the structure changes you can lose all enzyme activity: can also explain a lot of biochemical processes. Functions are influenced by interactions with other molecules. Interactions can be very stable: prosthetic group: a compound/cofactor that is permanently associated with a protein (always bound) and is required for its function. Interactions can be transient and short lives: a bind could last for only a couple minutes or hours. Ligand: a molecule that is bound reversibly by a protein. Binding site: position on a protein that interacts with a ligand. Complementary in size, shape, charge and hydrophobic/hydrophilic properties (all required for binding) Induced fit: structural adaptation between protein and ligand.
